Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 55 Researches
7.7
USERS' SCORE
Moderately Good
Based on 95 Reviews
7.7
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Proprietary Probiotic BlendLacticaseibacillus rhamnosus R0011Lactobacillus helvetius R0052Pediococcus acidilactici R1001Lacticaseibacillus casei R0215Bifidobacterium longum BB536Lactiplantibacillus plantarum R1012Bifidobacterium breve R0070Lactococcus lactis subsp. lactis R1058
131 mg (10 Billion CFU)
†
Top Medical Research Studies
9.5
We assessed the effectiveness of a probiotic blend of two Lactobacillus strains in treating diarrhea-predominant irritable bowel syndrome (IBS-D) through a randomized, single-blinded trial. Involving 100 patients, one group received standard IBS treatment while the other added probiotics.
After 12 weeks, both groups experienced symptom relief, but the probiotic group showed a greater decrease in their IBS symptoms. Remarkably, all patients on probiotics either found complete symptom relief or had mild symptoms, compared to over 14% of those on standard treatment who still experienced moderate IBS.
After 12 weeks, both groups experienced symptom relief, but the probiotic group showed a greater decrease in their IBS symptoms. Remarkably, all patients on probiotics either found complete symptom relief or had mild symptoms, compared to over 14% of those on standard treatment who still experienced moderate IBS.
Read More
A randomized, double-blind, placebo-controlled trial exploring CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) revealed promising results for diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that after 12 weeks, both ES1 and HT-ES1 significantly reduced symptom severity compared to a placebo, as shown by lower IBS-Symptom Severity Scale scores.
Other improvements included better stool consistency and quality of life. This study marks a breakthrough with the first positive findings for a probiotic or postbiotic from this strain specifically for IBS-D patients.
We found that after 12 weeks, both ES1 and HT-ES1 significantly reduced symptom severity compared to a placebo, as shown by lower IBS-Symptom Severity Scale scores.
Other improvements included better stool consistency and quality of life. This study marks a breakthrough with the first positive findings for a probiotic or postbiotic from this strain specifically for IBS-D patients.
Read More
9
We aimed to understand how Lacticaseibacillus rhamnosus IDCC 3201 (RH 3201) affects irritable bowel syndrome with constipation (IBS-C) through a thorough study. In a randomized, double-blind trial, 30 participants took either RH 3201 or a placebo for 8 weeks.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
Read More
Most Useful Reviews
9
Boosted immunity
72 people found this helpful
Live unconditionally! I've noticed a significant improvement in my immune system, especially with my irritable bowel syndrome. Consuming yogurt daily and two eggs has made a tremendous difference alongside taking this product weekly. A family member had a heavy condition but improved dramatically within a week. I've seen excellent effects and have even gifted it to friends, who reported positive outcomes too. I truly trust this product for its effectiveness and lack of side effects.
Read More
9
Normalised bowel movement
36 people found this helpful
I believe probiotics are incredibly effective! I initially received a gift of this product and was amazed by the immediate results; my bowel movements normalised, and skin inflammation decreased. Although I've tried cheaper options with more bacteria, none worked as well as this.
Read More
9
Digestion improvement
18 people found this helpful
This product has effectively resolved my digestive issues and enhanced my bowel function! Despite being lactose intolerant and sensitive to grains, this has worked brilliantly for me. I take it before meals and at bedtime, and the results have been remarkable.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 55 Researches
7.7
- All Researches
9.5
Our evaluation focused on the effectiveness of combining probiotics with trimebutine for treating irritable bowel syndrome (IBS). Through a systematic review of 37 randomized controlled trials involving 4,360 participants, we found that this combination therapy significantly outperformed trimebutine alone.
The effective rate was an impressive 93.5% for those receiving both treatments compared to just 73.8% for trimebutine alone. Notably, while side effects were mild in both groups, the combination therapy displayed a favorable safety profile. This suggests that using specific probiotic strains can enhance the treatment outcome for individuals with IBS.
The effective rate was an impressive 93.5% for those receiving both treatments compared to just 73.8% for trimebutine alone. Notably, while side effects were mild in both groups, the combination therapy displayed a favorable safety profile. This suggests that using specific probiotic strains can enhance the treatment outcome for individuals with IBS.
Read More
9.5
We assessed the effectiveness of a probiotic blend of two Lactobacillus strains in treating diarrhea-predominant irritable bowel syndrome (IBS-D) through a randomized, single-blinded trial. Involving 100 patients, one group received standard IBS treatment while the other added probiotics.
After 12 weeks, both groups experienced symptom relief, but the probiotic group showed a greater decrease in their IBS symptoms. Remarkably, all patients on probiotics either found complete symptom relief or had mild symptoms, compared to over 14% of those on standard treatment who still experienced moderate IBS.
After 12 weeks, both groups experienced symptom relief, but the probiotic group showed a greater decrease in their IBS symptoms. Remarkably, all patients on probiotics either found complete symptom relief or had mild symptoms, compared to over 14% of those on standard treatment who still experienced moderate IBS.
Read More
A randomized, double-blind, placebo-controlled trial exploring CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) revealed promising results for diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that after 12 weeks, both ES1 and HT-ES1 significantly reduced symptom severity compared to a placebo, as shown by lower IBS-Symptom Severity Scale scores.
Other improvements included better stool consistency and quality of life. This study marks a breakthrough with the first positive findings for a probiotic or postbiotic from this strain specifically for IBS-D patients.
We found that after 12 weeks, both ES1 and HT-ES1 significantly reduced symptom severity compared to a placebo, as shown by lower IBS-Symptom Severity Scale scores.
Other improvements included better stool consistency and quality of life. This study marks a breakthrough with the first positive findings for a probiotic or postbiotic from this strain specifically for IBS-D patients.
Read More
9
Probiotics support intestinal health
We assessed how a multi-strain probiotic, Serobioma, affects gut health in individuals with Irritable Bowel Syndrome (IBS). This study involved IBS patients and healthy controls, looking at how Serobioma interacts with mucosal mediators from IBS patients' biopsies.
Remarkably, Serobioma improved the integrity of intestinal cell layers affected by IBS mediators, particularly in patients with diarrhea and mixed bowel habits. It successfully countered increased permeability, indicating its potential to support gut barrier function in IBS.
Remarkably, Serobioma improved the integrity of intestinal cell layers affected by IBS mediators, particularly in patients with diarrhea and mixed bowel habits. It successfully countered increased permeability, indicating its potential to support gut barrier function in IBS.
Read More
9
Synbiotic reduced IBS pain effectively
We explored the effects of a new synbiotic combination of chitin-glucan (CG) and NCFM in a rat model of irritable bowel syndrome (IBS).
After nine weeks, we found that both CG and NCFM reduced abdominal pain when used separately, but together, they significantly lessened visceral pain and intestinal inflammation.
Not only did this combination improve pain perception, but it also reduced colon lesions and inflammation markers. Overall, our findings suggest that this synbiotic approach holds promise for alleviating IBS symptoms.
After nine weeks, we found that both CG and NCFM reduced abdominal pain when used separately, but together, they significantly lessened visceral pain and intestinal inflammation.
Not only did this combination improve pain perception, but it also reduced colon lesions and inflammation markers. Overall, our findings suggest that this synbiotic approach holds promise for alleviating IBS symptoms.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 95 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Boosted immunity
72 people found this helpful
Live unconditionally! I've noticed a significant improvement in my immune system, especially with my irritable bowel syndrome. Consuming yogurt daily and two eggs has made a tremendous difference alongside taking this product weekly. A family member had a heavy condition but improved dramatically within a week. I've seen excellent effects and have even gifted it to friends, who reported positive outcomes too. I truly trust this product for its effectiveness and lack of side effects.
Read More
9
Normalised bowel movement
36 people found this helpful
I believe probiotics are incredibly effective! I initially received a gift of this product and was amazed by the immediate results; my bowel movements normalised, and skin inflammation decreased. Although I've tried cheaper options with more bacteria, none worked as well as this.
Read More
9
Digestion improvement
18 people found this helpful
This product has effectively resolved my digestive issues and enhanced my bowel function! Despite being lactose intolerant and sensitive to grains, this has worked brilliantly for me. I take it before meals and at bedtime, and the results have been remarkable.
Read More
9
Regular bowel movements
18 people found this helpful
After a week of taking this product, I experienced less gas and a regular flow of stool each morning. My mother, who has irritable bowel syndrome, also benefited from it. She struggled with inconsistent bowel movements but now sees promising results. I am thoroughly impressed and will continue using it.
Read More
9
Consistent stool health
12 people found this helpful
After switching to capsules, I noticed that my body has adapted well, leading to regular bowel movements. I’ve tried similar products before, but none worked as effectively as this. My mother also enjoys it and has experienced positive effects. I will continue using it for ongoing health.
Read More
Frequently Asked Questions
9
Regular bowel movements
18 people found this helpful
After a week of taking this product, I experienced less gas and a regular flow of stool each morning. My mother, who has irritable bowel syndrome, also benefited from it. She struggled with inconsistent bowel movements but now sees promising results. I am thoroughly impressed and will continue using it.
9
Normalised bowel movements
2 people found this helpful
After trying various probiotics without success, I decided to try this one for my chronic gastrointestinal issues. In under a week on four capsules daily, my bowel movements stabilised, and my lactose intolerance improved. I found that reducing the dosage led to a return of symptoms, so I will continue with four capsules daily for the best results.
9
Improved stomach health
2 people found this helpful
I've dealt with stomach and bowel issues for ages, trying various probiotics without success. However, Jarro-Dophilus has transformed my health. After starting it months ago, my digestive system is vastly improved, and I'm now 'regular'. If you're struggling like I was, I highly recommend giving this product a try.
10
Effective treatment
10 people found this helpful
Jarow Formulas has been instrumental in my health, containing eight essential intestinal bacteria. Thanks to this product, I no longer suffer from irritable bowel syndrome. I'm truly grateful.
9
Normalised bowel movement
36 people found this helpful
I believe probiotics are incredibly effective! I initially received a gift of this product and was amazed by the immediate results; my bowel movements normalised, and skin inflammation decreased. Although I've tried cheaper options with more bacteria, none worked as well as this.
9
Skin improvement
1 people found this helpful
This probiotic is necessary for me and very affordable. It has improved my skin conditions like acne, rash, and dermatitis. My bowel movements have also become more regular compared to before.
9
Boosted immunity
72 people found this helpful
Live unconditionally! I've noticed a significant improvement in my immune system, especially with my irritable bowel syndrome. Consuming yogurt daily and two eggs has made a tremendous difference alongside taking this product weekly. A family member had a heavy condition but improved dramatically within a week. I've seen excellent effects and have even gifted it to friends, who reported positive outcomes too. I truly trust this product for its effectiveness and lack of side effects.
9
Digestion improvement
18 people found this helpful
This product has effectively resolved my digestive issues and enhanced my bowel function! Despite being lactose intolerant and sensitive to grains, this has worked brilliantly for me. I take it before meals and at bedtime, and the results have been remarkable.
9
Probiotics support intestinal health
We assessed how a multi-strain probiotic, Serobioma, affects gut health in individuals with Irritable Bowel Syndrome (IBS). This study involved IBS patients and healthy controls, looking at how Serobioma interacts with mucosal mediators from IBS patients' biopsies.
Remarkably, Serobioma improved the integrity of intestinal cell layers affected by IBS mediators, particularly in patients with diarrhea and mixed bowel habits. It successfully countered increased permeability, indicating its potential to support gut barrier function in IBS.
Remarkably, Serobioma improved the integrity of intestinal cell layers affected by IBS mediators, particularly in patients with diarrhea and mixed bowel habits. It successfully countered increased permeability, indicating its potential to support gut barrier function in IBS.
9
Probiotics effective for IBS relief
We aimed to explore the effectiveness of probiotics in managing irritable bowel syndrome (IBS). By reviewing 52 rigorous trials with nearly 6,300 participants, we found that probiotics significantly enhanced overall symptom relief, improved subjective well-being, and alleviated abdominal pain.
Notably, a daily dose of 10 billion cfu seemed particularly beneficial, with effects visible as early as four weeks into treatment. While probiotics demonstrated clear advantages, the roles of prebiotics and synbiotics remain less certain due to limited studies.
Notably, a daily dose of 10 billion cfu seemed particularly beneficial, with effects visible as early as four weeks into treatment. While probiotics demonstrated clear advantages, the roles of prebiotics and synbiotics remain less certain due to limited studies.
5
We examined the effectiveness of Lactobacillus and other probiotics in treating irritable bowel syndrome (IBS) through a thorough review of 82 clinical trials involving over 10,000 patients. The results indicated that while some probiotics, particularly certain Escherichia strains, showed moderate benefits for general symptoms, the effectiveness of Lactobacillus strains was generally rated as low to very low. Importantly, the risk of adverse events did not increase significantly with probiotic use. Overall, evidence supporting probiotics for IBS remains uncertain.
References
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- Wei JJ, Zhang PH, Yang ZY, Liu LP, Lian TT, et al. Colonoscopic administration of probiotics to treat irritable bowel syndrome with predominant diarrhea: a randomized placebo-controlled clinical trial. Surg Endosc. 2025;39:1893. doi:10.1007/s00464-025-11542-6
- Gąsiorowska A, Romanowski M, Walecka-Kapica E, Kaczka A, Chojnacki C, et al. Efficacy and Safety of a Mixture of Microencapsulated Sodium Butyrate, Probiotics, and Short Chain Fructooligosaccharides in Patients with Irritable Bowel Syndrome-A Randomized, Double-Blind, Placebo-Controlled Study. J Clin Med. 2024;14. doi:10.3390/jcm14010006
- Yu QX, Wang DD, Dong PJ, Zheng LH. Probiotics Combined With Trimebutine for the Treatment of Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis. J Gastroenterol Hepatol. 2025;40:677. doi:10.1111/jgh.16858
- Capirchio L, Rousseaux C, Dubuquoy C, Ouwehand AC, Maquet V, et al. A Synbiotic Combining Chitin-Glucan and NCFM Induces a Colonic Molecular Signature Soothing Intestinal Pain and Inflammation in an Animal Model of IBS. Int J Mol Sci. 2024;25. doi:10.3390/ijms251910732
- Biskou O, Walter S, Israelsen H, Winberg ME, Bednarska O, et al. ReFerm: a postbiotic fermented oat gruel composition is reducing mast cell degranulation in the colon of patients with irritable bowel syndrome. Front Med (Lausanne). 2024;11:1408623. doi:10.3389/fmed.2024.1408623
- Wu Y, Li Y, Zheng Q, Li L. The Efficacy of Probiotics, Prebiotics, Synbiotics, and Fecal Microbiota Transplantation in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis. Nutrients. 2024;16. doi:10.3390/nu16132114
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- Chang YH, Choi YJ, Shin CM, Moon JS, Kim TY, et al. Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. J Neurogastroenterol Motil. 2024;30:73. doi:10.5056/jnm23036
- Drozdov VN, Shikh EV, Astapovskii AA, Khalaidzheva KN, Solovieva SA, et al. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Vopr Pitan. 2023;92:92. doi:10.33029/0042-8833-2023-92-4-92-103
- Zhang WX, Shi LB, Zhou MS, Wu J, Shi HY. Efficacy of probiotics, prebiotics and synbiotics in irritable bowel syndrome: a systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials. J Med Microbiol. 2023;72. doi:10.1099/jmm.0.001758
- Goodoory VC, Khasawneh M, Black CJ, Quigley EMM, Moayyedi P, et al. Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis. Gastroenterology. 2023;165:1206. doi:10.1053/j.gastro.2023.07.018
- Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. doi:10.1038/s41598-024-72887-x
- Zhang L, Ni X, Jiang M, Du M, Zhang S, et al. Strains for Alleviation of Irritable Bowel Disease and Chronic Fatigue Syndrome. Microorganisms. 2024;12. doi:10.3390/microorganisms12061081
- Skrzydło-Radomańska B, Prozorow-Król B, Cichoż-Lach H, Majsiak E, Bierła JB, et al. The Effectiveness of Synbiotic Preparation Containing and Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study. Nutrients. 2020;12. doi:10.3390/nu12071999
- Bonfrate L, Di Palo DM, Celano G, Albert A, Vitellio P, et al. Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients. Eur J Clin Invest. 2020;50:e13201. doi:10.1111/eci.13201
- Ding FCL, Karkhaneh M, Zorzela L, Jou H, Vohra S. Probiotics for paediatric functional abdominal pain disorders: A rapid review. Paediatr Child Health. 2019;24:383. doi:10.1093/pch/pxz036
- Nocerino R, Di Costanzo M, Bedogni G, Cosenza L, Maddalena Y, et al. Dietary Treatment with Extensively Hydrolyzed Casein Formula Containing the Probiotic Lactobacillus rhamnosus GG Prevents the Occurrence of Functional Gastrointestinal Disorders in Children with Cow's Milk Allergy. J Pediatr. 2019;213:137. doi:10.1016/j.jpeds.2019.06.004
- Hojsak I. Probiotics in Functional Gastrointestinal Disorders. Adv Exp Med Biol. 2019;1125:121. doi:10.1007/5584_2018_321
- Han X, Lee A, Huang S, Gao J, Spence JR, et al. Lactobacillus rhamnosus GG prevents epithelial barrier dysfunction induced by interferon-gamma and fecal supernatants from irritable bowel syndrome patients in human intestinal enteroids and colonoids. Gut Microbes. 2019;10:59. doi:10.1080/19490976.2018.1479625
- Preston K, Krumian R, Hattner J, de Montigny D, Stewart M, et al. Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study. Benef Microbes. 2018;9:697. doi:10.3920/BM2017.0105
- Wegh CAM, Benninga MA, Tabbers MM. Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review. J Clin Gastroenterol. 2018;52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, held in Rome, Italy from September 10 to 12, 2017:S10. doi:10.1097/MCG.0000000000001054
- Darbaky Y, Evrard B, Patrier S, Falenta J, Garcin S, et al. Oral probiotic treatment of Lactobacillus rhamnosus Lcr35 prevents visceral hypersensitivity to a colonic inflammation and an acute psychological stress. J Appl Microbiol. 2017;122:188. doi:10.1111/jam.13320
- Yoon H, Park YS, Lee DH, Seo JG, Shin CM, et al. Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Biochem Nutr. 2015;57:129. doi:10.3164/jcbn.15-14
- Cruchet S, Furnes R, Maruy A, Hebel E, Palacios J, et al. The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. Paediatr Drugs. 2015;17:199. doi:10.1007/s40272-015-0124-6
- Martin FP, Cominetti O, Berger B, Combremont S, Marquis J, et al. Metabolome-associated psychological comorbidities improvement in irritable bowel syndrome patients receiving a probiotic. Gut Microbes. 2024;16:2347715. doi:10.1080/19490976.2024.2347715
- Srivastava S, Basak U, Naghibi M, Vijayakumar V, Parihar R, et al. A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome. Gut Microbes. 2024;16:2338322. doi:10.1080/19490976.2024.2338322
- Lenoir M, Wienke J, Fardao-Beyler F, Roese N. An 8-Week Course of Bifidobacterium longum 35624 Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Probiotics Antimicrob Proteins. 2025;17:315. doi:10.1007/s12602-023-10151-w
- Khoo XH, Chong CW, Talha AM, Philip K, Teh CS, et al. The impact of diet and ethnicity on gut microbiota variation in irritable bowel syndrome: A multi-center study. J Gastroenterol Hepatol. 2023;38:1259. doi:10.1111/jgh.16174
- Nakamura Y, Suzuki S, Murakami S, Nishimoto Y, Higashi K, et al. Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by BB536 supplementation: A RCT. Comput Struct Biotechnol J. 2022;20:5847. doi:10.1016/j.csbj.2022.10.026
- Yakovenko EP, Strokova TV, Ivanov AN, Iakovenko AV, Gioeva IZ, et al. [The effectiveness of a probiotic containing Bifidobacterium longum BB-46 and Enterococcus faecium ENCfa-68 in the treatment of post-infectious irritable bowel syndrome. Prospective randomized comparative study]. Ter Arkh. 2022;94:180. doi:10.26442/00403660.2022.02.201368
- Groeger D, Murphy EF, Tan HTT, Larsen IS, O'Neill I, et al. Interactions between symptoms and psychological status in irritable bowel syndrome: An exploratory study of the impact of a probiotic combination. Neurogastroenterol Motil. 2023;35:e14477. doi:10.1111/nmo.14477
- Sabaté JM, Iglicki F. Effect of 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol. 2022;28:732. doi:10.3748/wjg.v28.i7.732
- Di Pierro F, Pane M. Bifidobacterium longum W11: Uniqueness and individual or combined clinical use in association with rifaximin. Clin Nutr ESPEN. 2021;42:15. doi:10.1016/j.clnesp.2020.12.025
- Caviglia GP, Tucci A, Pellicano R, Fagoonee S, Rosso C, et al. Clinical Response and Changes of Cytokines and Zonulin Levels in Patients with Diarrhoea-Predominant Irritable Bowel Syndrome Treated with ES1 for 8 or 12 Weeks: A Preliminary Report. J Clin Med. 2020;9. doi:10.3390/jcm9082353
- Buhner S, Hahne H, Hartwig K, Li Q, Vignali S, et al. Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients. PLoS One. 2018;13:e0193943. doi:10.1371/journal.pone.0193943
- JanssenDuijghuijsen L, van den Belt M, Rijnaarts I, Vos P, Guillemet D, et al. Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial. Eur J Nutr. 2024;63:1983. doi:10.1007/s00394-024-03398-8
- Skrzydło-Radomańska B, Prozorow-Król B, Kurzeja-Mirosław A, Cichoż-Lach H, Laskowska K, et al. The Efficacy and Safety of Single-Strain Probiotic Formulations Containing or in Adult Patients with Irritable Bowel Syndrome-A Randomized Double-Blind Placebo-Controlled Three-Arm Interventional Trial. J Clin Med. 2023;12. doi:10.3390/jcm12144838
- Boonma P, Shapiro JM, Hollister EB, Badu S, Wu Q, et al. Probiotic VSL#3 Treatment Reduces Colonic Permeability and Abdominal Pain Symptoms in Patients With Irritable Bowel Syndrome. Front Pain Res (Lausanne). 2021;2:691689. doi:10.3389/fpain.2021.691689
- Xu H, Ma C, Zhao F, Chen P, Liu Y, et al. Adjunctive treatment with probiotics partially alleviates symptoms and reduces inflammation in patients with irritable bowel syndrome. Eur J Nutr. 2021;60:2553. doi:10.1007/s00394-020-02437-4
- Szajewska H, Hojsak I. Health benefits of GG and subspecies BB-12 in children. Postgrad Med. 2020;132:441. doi:10.1080/00325481.2020.1731214
- Martoni CJ, Srivastava S, Leyer GJ. DDS-1 and UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. Nutrients. 2020;12. doi:10.3390/nu12020363
- Le Nevé B, Derrien M, Tap J, Brazeilles R, Cools Portier S, et al. Fasting breath H2 and gut microbiota metabolic potential are associated with the response to a fermented milk product in irritable bowel syndrome. PLoS One. 2019;14:e0214273. doi:10.1371/journal.pone.0214273
- Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, et al. Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019;11:627. doi:10.1007/s12602-018-9401-3
- Baştürk A, Artan R, Yılmaz A. Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial. Turk J Gastroenterol. 2016;27:439. doi:10.5152/tjg.2016.16301
- Eskesen D, Jespersen L, Michelsen B, Whorwell PJ, Müller-Lissner S, et al. Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial. Br J Nutr. 2015;114:1638. doi:10.1017/S0007114515003347
- Veiga P, Pons N, Agrawal A, Oozeer R, Guyonnet D, et al. Changes of the human gut microbiome induced by a fermented milk product. Sci Rep. 2014;4:6328. doi:10.1038/srep06328
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- Gomes P, Laroute V, Beaufrand C, Bézirard V, Aubry N, et al. Postbiotic potential of Lactococcus lactis CNCM I-5388 in alleviating visceral pain in female rat through GABA production: The innovative concept of the "active-GAD bag". FASEB J. 2025;39:e70383. doi:10.1096/fj.202401125RR
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